LCA

Mar 29

Progression of PROM1-Associated Retinal Degeneration as Determined by Spectral-Domain Optical Coherence Tomography Over a 24-Month Period

Significant thickness losses could be detected in outer retinal layers by SD-OCT over a 24-month period in patients with PROM1-associated RD

Jul 4, 2021

The LRAT−/− RAT: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for RP

Researchers developed and phenotyped a pigmented knockout rat model for lecithin retinol acyltransferase (LRAT) using CRISPR/Cas9.

May 16, 2021

Dissecting the role of EYS in retinal degeneration: clinical and molecular aspects and its implications for future therapy

Ana B. Garcia-Delgado , Lourdes Valdes-Sanchez , Maria Jose Morillo-Sanchez , Beatriz Ponte-Zuñiga , Francisco J. Diaz-Corrales , Berta...

Mar 12, 2021

LCA, early-onset severe retinal dystrophy: current management and clinical trials

RPE65-related LCA pivotal trials, . . . have paved the way for a new era of genetic treatments in ophthalmology.

Jun 26, 2018

Sawar Zahid MS, MD, Kari Branham MS, CGC, Dana Schlegel MS, MPH, CGC, Mark E. Pennesi MD, PhD, Michel Michaelides MB, MD, John...

Jun 29, 2012

Early Onset Retinal Dystrophy Due to Mutations in LRAT:

Phenotypic similarities to the retinal dysfunction assoc. with RPE65 mutations, suggest that LRAT deficiency may respond to novel therapies.

Oct 29, 1999

Leber Congenital Amaurosis

Leber's congenital amaurosis (LCA) is the earliest, most severe form of inherited retinal dystrophies responsible for congenital blindness.

WHAT WE HOPE TO UNDERSTAND