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Multigenerational Autosomal Recessive Best Disease
Retinal findings raised suspicion for this inherited retinal disease, confirmed with genetic testing.
Nov 30, 2024


New Gene Therapy for Retinitis Pigmentosa Shows Promise
New research . . . suggests that a new kind of gene therapy can improve vision in people who have lost nearly all sight to RP.
Oct 20, 2024


Progression of PROM1-Associated Retinal Degeneration as Determined by Spectral-Domain Optical Coherence Tomography Over a 24-Month Period
Significant thickness losses could be detected in outer retinal layers by SD-OCT over a 24-month period in patients with PROM1-associated RD
Mar 30, 2024


Gene Therapy Improves Functional Measures in XLRP
Patients with XLRP treated with AGTC-501 gene therapy experienced improvements in visual function including retinal sensitivity . . .
Mar 14, 2024


Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration
Presents a soft artificial retina where flexible ultrathin photosensitive transistors are integrated with three-dimensional stimulation . .
Jan 15, 2024


Potential of endogenous regenerative technology for in situ regenerative medicine
Endogenous regenerative technology involves the use of a patient's biologically active proteins, growth factors and biomaterial scaffolds.
Jul 23, 2022


A new hope for a therapy against retinitis pigmentosa
June 17, 2022 | Université de Genève Journal Reference Olivier Mercey, Corinne Kostic, Eloïse Bertiaux, Alexia Giroud, Yashar Sadian,...
Jun 17, 2022


Antabuse may help revive vision in people with progressive blinding disorders
UC Berkeley researchers have found that a drug once widely used to wean alcoholics off drinking may help improve sight in mice with RD.
Mar 18, 2022


New Treatments for Retinitis Pigmentosa
Existing treatments only help a fraction of the estimated 100,000 Americans with this condition. But advances in gene therapy may soon help.
Aug 16, 2021


CRISPR/Cas9 Gene Editing
X-linked RP caused by RPGR mutations, an attractive target for gene therapy because of its clinical severity and large number of patients.
Jul 13, 2021


Dissecting the role of EYS in retinal degeneration: clinical and molecular aspects and its implications for future therapy
Ana B. Garcia-Delgado , Lourdes Valdes-Sanchez , Maria Jose Morillo-Sanchez , Beatriz Ponte-Zuñiga , Francisco J. Diaz-Corrales , Berta...
May 17, 2021


FDA grants orphan drug designation for RP treatment
The FDA has granted orphan drug designation for chemically induced photoreceptor-like cells to treat retinitis pigmentosa.
Mar 15, 2021


Genome Editing in Retinal Diseases using CRISPR Technology
By: Glenn Yiu, MD, PhD - Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, California
Ophthalmology
Mar 7, 2021


FDA grants fourth ODD for treatment of PDE6B gene mutation-associated retinal diseases
FDA granted 4th Orphan Drug Designation for novel gene therapy product candidate (OCU400, Ocugen Inc.) in treatment of PDE6B gene mutation.
Aug 12, 2020


New gene therapy technique
Shows promise in stem cell model of retinitis pigmentosa Although the 2017 FDA approval of Spark Therapeutics’ gene therapy Luxturna was...
Jun 10, 2020


CRISPR start, RP first, 50-year case
By Keng Jin Lee and Kanaga Rajan
Published JAN 31, 2020
Jan 31, 2020


Understanding the molecular mechanisms underlying retina degeneration in INPP5E-Joubert Syndrome
Our goal is to identify the onset of degeneration and devise gene-based therapies to ameliorate or cure the retina disease.
Jul 15, 2018


First Gene Therapy FDA-Approved for an Inherited Retinal Disease
In 1972, Friedman and Roblin proposed that it was theoretically possible to introduce “good” DNA to replace defective DNA.
Apr 1, 2018


FDA Approves Gene Therapy for Inherited Blindness Developed by the UPenn and CHOP
In 2017, the FDA approved a gene therapy for RP caused by RPE65. The decision marked the first approved treatment for any form RP.
Dec 19, 2017


Precision Medicine:
Stem cell-derived cell transplantation in the eye is one therapy being explored for inherited retinal degenerations such as RP.
Jan 27, 2016
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