Clinical Trials
Recruiting Patients
RPGR
STATUS OF TRIAL
Recruiting
Gene Therapy Trial, due to RPGR
BRIEF DESCRIPTION
Gene Therapy Trial for the Treatment of XLRP Associated With Variants in the RPGR Gene. ClinicalTrials.gov Identifier: NCT04671433
INTERVENTION
Biological: Genetic: AAV5-RPGR
STUDY RESULTS
No Results Available
INSTITUTION
Aaron Los Nagiel, Vitreol Retinal Assoc, Emory Eye Centre, Mass Eye & Ear, Univ of MI, Retinal Cons of Houston
LOCATION
USA
RPGR
STATUS OF TRIAL
Recruiting
Natural History Study With Mutations in RPGR
BRIEF DESCRIPTION
Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR)
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
Shiley Eye Inst, Emory Eye Ctr, Mass Eye & Ear Infirmary, Kellogg Eye Ctr, UPMC Eye Ctr, Hosp for Sick Children, Moorfields Eye Hosp
LOCATION
USA, Canada UK
RPGR
STATUS OF TRIAL
Recruiting
Safety/Efficacy of rAAV2tYF-GRK1- RPGR Mutations
BRIEF DESCRIPTION
Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
INTERVENTION
Biological: rAAV2tYF-GRK1-RPGR
STUDY RESULTS
No Results Available
INSTITUTION
Univ of FL, Boston Children's Hosp, Columbia Univ, Duke Eye Ctr, Cincinnati Eye Inst, Casey Eye Inst, Oregon Health & Science, Retina Found of SW
LOCATION
FL, MA, NY, NC, OH, OR, TX (USA)
RPGR
STATUS OF TRIAL
Recruiting
Gene Therapy Trial - Variants in RPGR
BRIEF DESCRIPTION
Follow-up Gene Therapy Trial for the Treatment of XLRP Associated With Variants in the RPGR Gene. ClinicalTrials.gov Identifier: NCT04794101
INTERVENTION
Biological: Genetic: AAV5-RPGR 4e11|Biological: Genetic: AAV5-RPGR 2e11
STUDY RESULTS
No Results Available
INSTITUTION
Children's Hosp LA, Vitreo Retinal Assoc, Emory Eye Ctr, Boston Eye & Ear, Univ of MI Retinal Cons of Houston
LOCATION
USA
RPE65
STATUS OF TRIAL
Recruiting
Natural History IRD due to RPE65
BRIEF DESCRIPTION
Natural History of Patients With Inherited Retinal Diseases Due to Mutations in RPE65 Gene
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
UOC, AOU, IRCCS
LOCATION
Camposampiero, Florence, Milan, Naples, Rome, Pavia (Italy)
RLBP1
STATUS OF TRIAL
Recruiting
Proof of Concept Study, CPK850 for RLBP1
BRIEF DESCRIPTION
A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa
INTERVENTION
Biological: CPK850
STUDY RESULTS
No Results Available
INSTITUTION
Novartis Investigative Site
LOCATION
Stockholm, Sweden
RHO
STATUS OF TRIAL
Recruiting
HCQ for RP due to P23H Mutation
BRIEF DESCRIPTION
Oral Hydroxychloroquine (HCQ) for Retinitis Pigmentosa Caused by P23H- Rhodopsin (RHO)
INTERVENTION
Drug: Hydroxychloroquine lower dose|Drug: Hydroxychloroquine higher dose
STUDY RESULTS
No Results Available
INSTITUTION
University of Michigan
LOCATION
Ann Arbor, MI, USA
RHO
STATUS OF TRIAL
Recruiting
QR-1123 in Subjects With RP Due to P23H Mutation in RHO
BRIEF DESCRIPTION
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
INTERVENTION
Drug: QR-1123|Other: Sham procedure
STUDY RESULTS
No Results Available
INSTITUTION
Sue Anschutz-Rogers Eye Ctr, Vitreo Retinal Assoc, Shriners UK Ophth, Casey Eye Inst, Retina Found SW
LOCATION
Colorado, Florida, Kentucky, Oregon, Texas (USA)
PDE6B
STATUS OF TRIAL
Recruiting
Safety/Efficacy Study - RP Due to PDE6B
BRIEF DESCRIPTION
Safety and Efficacy Study in Patients With Retinitis Pigmentosa Due to Mutations in PDE6B Gene
INTERVENTION
Biological: AAV2/5-hPDE6B
STUDY RESULTS
No Results Available
INSTITUTION
Clinique Ophtalmologique
LOCATION
Nantes, France
PCDH15
STATUS OF TRIAL
Recruiting
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F
BRIEF DESCRIPTION
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
UCSF, Advanced Eye Care, Wilmer Eye Inst, Hosp for Sick Children, Univ of Tubingen, Haddassah Med Ctr, Radboud Univ
LOCATION
USA, Canada, Germany, Israel, Netherlands
EYS
STATUS OF TRIAL
Recruiting
Rate of Progression - EYS
BRIEF DESCRIPTION
Rate of Progression in EYS Related Retinal Degeneration
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
Assoc Retina Consultants, Stanford Ophth, Shiley Eye Inst, UCSF, CO Retina Assoc, NEI, Vitreo-Retinal Assoc, U of Miami, Emory Eye Ctr, U of KY, Wilmer Eye Inst, Mass Eye & Ear, Kellogg Eye Ctr, Duke Univ Eye Ctr, Casey Eye Inst, U of Pittsburgh, Retina Found SW, McPherson Eye Res Inst, Ghent Univ Hosp, Fed U of SÌ£o Paulo, Hosp for Sick Children, Helsinki U Hosp, Ctr Hosp Natl d'Ophth, U of Tubingen, Hadassah Med Ctr, Radboud U, U of Lublin
LOCATION
USA, Belgium, Brazil, Canada, Finland, France, Germany, Netherlands, Israel, Poland
CNGB1
STATUS OF TRIAL
Recruiting
CNGB1 and Allied Disorders
BRIEF DESCRIPTION
CNGB1 and Allied Disorders
INTERVENTION
Other: No intervention, this is a natural history progression study
STUDY RESULTS
No Results Available
INSTITUTION
S. H. Tsang, Wills Eye Hosp, Institut de la Vision, LMU Klinikum, Eberhard Karls Univ, Moorfields Eye Hosp
LOCATION
USA, France, Germany, UK
STATUS OF TRIAL
Recruiting
Multimodal Ophthalmic Imaging
BRIEF DESCRIPTION
Multimodal Ophthalmic Imaging
INTERVENTION
Device: High-resolution retinal imaging through adaptive optics|Device: High-resolution retinal imaging through holographic systems
STUDY RESULTS
No Results Available
INSTITUTION
Centre Hospitalier National d'Ophtalmologie des 15-20
LOCATION
Paris, France
STATUS OF TRIAL
Recruiting
Computer Aided Diagnosis from Color Fundus Photograph
BRIEF DESCRIPTION
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
INTERVENTION
Diagnostic Test: Software assisted imaging diagnosis
STUDY RESULTS
No Results Available
INSTITUTION
Peking Union Med College Hosp., Chinese Academy of Med Sciences, 2nd Hosp of Hebei Med Univ, West China Hosp of Sichuan Univ, Tianjin Med Univ Eye Hosp, WMU Zhejiang Eye Hosp
LOCATION
China
STATUS OF TRIAL
Recruiting
Sildenafil for Treatment of Choroidal Ischemia
BRIEF DESCRIPTION
Sildenafil for Treatment of Choroidal Ischemia
INTERVENTION
Drug: Sildenafil|Other: Standard of Care Sildenafil|Diagnostic Test: Ocular Coherence Tomography-Angiography (OCT-A)|Other: Visual Acuity (VA)
STUDY RESULTS
No Results Available
INSTITUTION
Edward Harkness Eye Institute
LOCATION
New York, NY, USA
STATUS OF TRIAL
Recruiting
Bimodal & Coaxial High Res Ophthalmic Imaging
BRIEF DESCRIPTION
Bimodal and Coaxial High Resolution Ophthalmic Imaging
INTERVENTION
Other: Bimodal high resolution imaging of the retina
STUDY RESULTS
No Results Available
INSTITUTION
Centre Hospitalier National d'Ophtalmologie des 15-20
LOCATION
Paris, France
STATUS OF TRIAL
Recruiting
Stem Cell Ophthalmology Treatment Study II
BRIEF DESCRIPTION
Stem Cell Ophthalmology Treatment Study II
INTERVENTION
Procedure: Arm 1|Procedure: Arm 2|Procedure: Arm 3
STUDY RESULTS
No Results Available
INSTITUTION
MD Stem Cells, MD Stem Cells, Medicare Orthopedics & Spine Hospital
LOCATION
USA & UAE
STATUS OF TRIAL
Recruiting
Visual Performance Measures to Assess Clinical Trial Outcomes
BRIEF DESCRIPTION
Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision
INTERVENTION
Device: Virtual Reality Headset based tests
STUDY RESULTS
No Results Available
INSTITUTION
NI Clinical Research Facility
LOCATION
Belfast, Northern Ireland, UK
STATUS OF TRIAL
Recruiting
Implantation of hESC - patients with Monogenic Mutation
BRIEF DESCRIPTION
Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation
INTERVENTION
Biological: Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)
STUDY RESULTS
No Results Available
INSTITUTION
Centre Hospitalier National d'Ophtalmologie (CHNO) des Quinze-Vingts, Paris, France
LOCATION
Centre Hospitalier National d'Ophtalmologie (CHNO) des Quinze-Vingts, Paris, France
STATUS OF TRIAL
Recruiting
Rod and Cone Mediated Function in Retinal Disease
BRIEF DESCRIPTION
Rod and Cone Mediated Function in Retinal Disease
INTERVENTION
Device: Medmont Darl Adapted Chromatic (DAC)|Device: RetMap, RM Electrode|Device: MonCvONE electrophysiology
STUDY RESULTS
No Results Available
INSTITUTION
National Institutes of Health Clinical Center
LOCATION
Bethesda, MD, USA
STATUS OF TRIAL
Recruiting
UMSCs for the Management of RP (RP)
BRIEF DESCRIPTION
Investigation of Therapeutic Efficacy and Safety of UMSCs for the Management of Retinitis Pigmentosa (RP)
INTERVENTION
Biological: Injection of stem cells in sub-tenon space of eye for the management of retinitis pigmentosa|Biological: Injection of stem cells in suprachoroidal space of eye for the management of Retinitis Pigmentosa
STUDY RESULTS
No Results Available
INSTITUTION
Stem Cell Lab, Jinnah Burn & Reconstructive Surgery Centre
LOCATION
Punjab, Pakistan
STATUS OF TRIAL
Recruiting
Growing-up With Rare Genetic Syndromes
BRIEF DESCRIPTION
GROWing Up With Rare GENEtic Syndromes
INTERVENTION
Diagnostic Test: Retrospective file studies
STUDY RESULTS
No Results Available
INSTITUTION
Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
LOCATION
Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
STATUS OF TRIAL
Recruiting
Effect of Oral Admin 9-cis
BRIEF DESCRIPTION
The Effect of Oral Administration of 9-cis, Carotene Rich Powder of the Alga Dunaliella Bardawil
INTERVENTION
Dietary Supplement: Alga Dunaliella Bardawil|Other: Placebo (starch)
STUDY RESULTS
No Results Available
INSTITUTION
Sheba Medical Center
LOCATION
Tel Hashomer, Israel
STATUS OF TRIAL
Recruiting
Dose-escalation Study - Safety & Tolerability of GS030
BRIEF DESCRIPTION
Dose-escalation Study to Evaluate the Safety and Tolerability of GS030 in Subjects With Retinitis Pigmentosa
INTERVENTION
Combination Product: Gene therapy: GS030-DP AND Medical device: GS030-MD
STUDY RESULTS
No Results Available
INSTITUTION
UPMC Eye Center, CHNP, Moorfields Eye Hospital
LOCATION
USA, France, UK
STATUS OF TRIAL
Recruiting
Subretinal Trans of Stem Cell Derived Retinal Pigment Epitheliums
BRIEF DESCRIPTION
Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa
INTERVENTION
Biological: Retinal pigment epitheliums transplantation
STUDY RESULTS
No Results Available
INSTITUTION
Beijing Tongren Hosp, Capital Med Univ
LOCATION
Beijing, China
STATUS OF TRIAL
Recruiting
Pilot Study of Intravitreal Autologous CD34+ Stem Cell Therapy for RP
BRIEF DESCRIPTION
Pilot Study of Intravitreal Autologous CD34+ Stem Cell Therapy for Retinitis Pigmentosa
INTERVENTION
Biological: Intravitreal autologous CD34+ cells
STUDY RESULTS
No Results Available
INSTITUTION
UC Davis
LOCATION
Davis, CA, USA
STATUS OF TRIAL
Recruiting
Validation of Standardized Test Protocols - Daily Life Activities
BRIEF DESCRIPTION
Validation of Standardized Test Protocols to Assess the Impact of Visual Pathologies in Daily Life Activities
INTERVENTION
Behavioral: performance of behavioral locomotion tasks phase 1|Behavioral: performance of behavioral locomotion tasks phase 2
STUDY RESULTS
No Results Available
INSTITUTION
Centre Hospitalier National d'Ophtalmologique
LOCATION
Paris, France
STATUS OF TRIAL
Recruiting
Environmental Localization Mapping and Guidance for Visual Prosthesis Users
BRIEF DESCRIPTION
Environmental Localization Mapping and Guidance for Visual Prosthesis Users
INTERVENTION
Device: Navigation System for Users of a Visual Prosthesis
STUDY RESULTS
No Results Available
INSTITUTION
Wilmer Eye Inst & Johns Hopkins Applied Physics Laboratory
LOCATION
Baltimore, MD, USA
STATUS OF TRIAL
Recruiting
Natural History - Progression of XLRP
BRIEF DESCRIPTION
Natural History of the Progression of X-Linked Retinitis Pigmentosa
INTERVENTION
Other: Other: Assessments
STUDY RESULTS
No Results Available
INSTITUTION
Multiple research sites
LOCATION
USA, Canada, Finland, Germany, Netherlands, United Kingdom
STATUS OF TRIAL
Recruiting
UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource
BRIEF DESCRIPTION
UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
Children's National Health System
LOCATION
Washington, D.C., USA
STATUS OF TRIAL
Recruiting
4D-125 in Patients with XLRP
BRIEF DESCRIPTION
4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)
INTERVENTION
Biological: 4D-125 IVT Injection|Other: Observational
STUDY RESULTS
No Results Available
INSTITUTION
Univ of CO, Kellogg Eye Ctr, Duke Univ Eye Ctr, Casey Eye Inst, Retina Found of SW, John A. Moran Eye Ctr
LOCATION
USA
STATUS OF TRIAL
Recruiting
Safety and Tolerability of hRPC
BRIEF DESCRIPTION
Safety and Tolerability of hRPC in Retinitis Pigmentosa
INTERVENTION
Drug: hRPC
STUDY RESULTS
No Results Available
INSTITUTION
Retinal Research Inst, Mass Eye & Ear Infirmary, Oregon Health & Sci Univ, Inst de la Macula, Oxford Eye Hosp
LOCATION
USA, Spain, UK
STATUS OF TRIAL
Recruiting
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
BRIEF DESCRIPTION
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
Sanford Health, Online Patient Enrollment System
LOCATION
USA, Australia
STATUS OF TRIAL
Recruiting
NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases
BRIEF DESCRIPTION
NR600 System Retinal Prosthesis for Patients With Retinal Degenerative Diseases
INTERVENTION
Device: Retinal surgery with implantation of epi-retinal device
STUDY RESULTS
No Results Available
INSTITUTION
UZ Ghent, UZ Leuven, Rabin Med Ctr, Sourasky Med Ctr, Fondazione Policlinico A. Gemelli
LOCATION
Belgium, Israel, Italy
STATUS OF TRIAL
Recruiting
RP Clinical Measures - Repeatability Testing- Potential Outcome Measures
BRIEF DESCRIPTION
Retinitis Pigmentosa Clinical Measures and Repeatability Testing of Potential Outcome Measures
INTERVENTION
STUDY RESULTS
No Results Available
INSTITUTION
NIH Clinical Center
LOCATION
Bethesda, MD, USA
STATUS OF TRIAL
Recruiting
Experimental & Clinical Studies, Retinal Stimulation
BRIEF DESCRIPTION
Experimental and Clinical Studies of Retinal Stimulation
INTERVENTION
Device: New visual processing unit (VPU) with asymmetric waveforms|Device: New VPU with bipolar stimulation
STUDY RESULTS
No Results Available
INSTITUTION
University of Michigan
LOCATION
Ann Arbor, Michigan, USA
STATUS OF TRIAL
Recruiting
Retrospective NIS - Benefit of TES
BRIEF DESCRIPTION
Retrospective NIS to Evaluate the Patient Benefit of TES
INTERVENTION
Device: Transcorneal Electrostimulation via OkuStim System
STUDY RESULTS
No Results Available
INSTITUTION
Univ Augenklinik Tübingen
LOCATION
Tübingen, Germany
STATUS OF TRIAL
Recruiting
Phenotype Correlates Genotype of Inherited Retina Dystrophies, RP, Con>Rod Dystrophies.
BRIEF DESCRIPTION
Phenotype Correlates Genotype of Inherited Retina Dystrophies, Retinitis Pigmentosa, Con>Rod Dystrophies.
INTERVENTION
Diagnostic Test: Retina Analysis-mosaic|Diagnostic Test: Autofluorescence|Diagnostic Test: OCT- 1 micra|Procedure: Genotype analysis
STUDY RESULTS
No Results Available
INSTITUTION
Retina & Genomics Institute
LOCATION
Merida, Yucatan, Mexico
STATUS OF TRIAL
Recruiting
Mobility Protocol - Advanced Visually Impaired Subjects
BRIEF DESCRIPTION
Mobility Protocol Adapted for Advanced Visually Impaired Subjects
INTERVENTION
Behavioral: Locomotion task|Behavioral: Posturology task SOT (Sensory Organization Test)|Behavioral: The quality of life questionnaire
STUDY RESULTS
No Results Available
INSTITUTION
Centre Hospitalier National d'Ophtalmologie des 15-20
LOCATION
Paris, France
STATUS OF TRIAL
Recruiting
Efficacy/Safety - Optogenetic Therapy in Adults
BRIEF DESCRIPTION
Efficacy and Safety of of vMCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]
INTERVENTION
Biological: Gene Therapy Product-vMCO-010|Procedure: Sham Injection
STUDY RESULTS
No Results Available
INSTITUTION
Nanoscope Clinical Site
LOCATION
USA, Puerto Rico